Cytocompatibility and Dielectric Properties of Sr2+ Substituted Nano-Hydroxyapatite for Triggered Drug Release

  • Lakshmanaperumal Sundarabharathi Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India
  • Mahendran Chinnaswamy Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamilnadu, India.
  • Hemalatha Parangusan Center for Advanced Materials, Qatar University, P. O. Box 2713, Doha, Qatar
  • Deepalekshmi Ponnamma Center for Advanced Materials, Qatar University, P. O. Box 2713, Doha, Qatar
  • Mariam Al Ali Al-Maadeed Materials Science and Technology Program, Qatar University, P. O. Box 2713, Doha, Qatar
Keywords: Hydroxyapatite, Sol-gel, doxycycline, Biocompatibility, Bone Implant


Hydroxyapatite (Ca5(PO4)3OH) is a well-known bioceramics material used in medical applications because of its ability to form direct chemical bonds with living tissues. In this context, we investigate the biocompatibility and dielectric properties of Sr2+-substituted hydroxyapatite nanoparticles were synthesized by sol-gel method. The influence of strontium on the crystal structure, functional group, morphological, electrical properties, and biocompatibility of as-synthesized nano-hydroxyapatite samples was analyzed using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FE-SEM). Dielectrical properties of the bioactive Sr-HA sample were investigated by a dielectric impedance spectroscopy method. The observed results illustrate the incorporation of Sr2+ ions in the apatite lattice could influence the pure HA properties, by reducing the crystallite size and crystallinity quite consistent with the morphology variation. The ac conductivity (σac) increased with an increasing applied frequency confirmed that prepared HA sample exhibited the universal power law nature. Further, the in vitro drug loading and release studies using doxycycline as a model drug demonstrate that the Sr2+ -HA nanoparticles show high drug adsorption capacity and sustained drug release. Thus, the improved bioceramics system could be a promising candidate for future biomedical applications.


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Shuyun Qi, Yanlin Huang, Yadong Li, PeiqingCai, Sun ll Kim and Hyo Jin Seo, Probe spectrum measurements of Eu3+ ions as a relevant tool for monitoring in vitro hydroxyapatite formation in a new borate biomaterial,J. Mater. Chem. B 2 (2014) 6387-6396.

Ruixue Sun, Kezheng Chen, Xiangfeng Wu, Dandan Zhao and Zhenzong Sun, Controlled synthesis and enhanced luminescence of europium-doped fluorine-substituted hydroxyapatite nanoparticles,Cryst. Eng. Comm. 15 (2013) 3442-3447.

Sophie C. Cox, ParastooJamshidi, Liam M. Grover andKajal K. Mallick, Preparation and characterisation of nanophaseSr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation, Mater. Sci. Eng C 35 (2014) 106-114.

D. Gopi, S. Nithiya, E. Shinyjoy and L. Kavitha. Spectroscopic investigation on formation and growth of mineralized nanohydroxyapatite for bone tissue engineering applications, Spectrochim. Acta. Part A. 92(2012)194-200.

Omer Kaygili, SerhatKeser, Mustafa Kom, YesariEroksuz, Sergey V. Dorozhkin andTankutAtes, Strontium substituted hydroxyapatites: Synthesis and determination of their structural properties, in vitro and in vivo performance,Mater. Sci. Eng C. 55 (2015) 538-546.

LakshmanaperumalSundarabharathi, MahendranChinnaswamy, DeepalekshmiPonnamma, HemalathaParangusan and Mariam Al Ali Al-Maadeed, Investigation of Antimicrobial Properties and in-vitro Bioactivity of Ce3+-Sr2+Dual-substituted nano Hydroxyapatites, J. Am. Ceram. Soc.102 (2018) 144-157.

S. Hesaraki, M. Alizadeh, H. Nazarian and D. Sharifi, Physico-chemical and in vitro biological evaluation of strontium/calcium silicophosphate glass, J. Mater. Sci. Mater. Med. 21 (2010) 695-705.

S. Lakshmanaperumal, P. Hemalatha, D. Ponnamma and C. Mahendran, In-vitro biocompatibility, bioactivity and photoluminescence properties of Eu3+/Sr2+ dual-doped nano-hydroxyapatite for biomedical Applications,J. Biomed. Mater. Res. B, 106 (2018) 2191-2201.

Matteo Frasnelli1, Francesco Cristofaro and Vincenzo M. Sglavo, Synthesis and characterization of strontium-substituted hydroxyapatite nanoparticles for bone regeneration,Mater. Sci. Eng. C 71 (2017) 653-662

R.V.Suganthi, K.Elayaraja, M.I.AhymahJoshy, C.V.Sarath, E.K.Girija and S.NarayanaKalkura, Fibrous Growth of Strontium substituted hydroxyapatite and its drug release, Mater.Sci. Eng. C 31(2011) 593-599.

V.H. Pham andN.N. Trung, Luminescence of europium doped silicon-substituted hydroxyapatite nanobiophosphor via a co-precipitation method,Mater. Lett. 136 (2014) 359-361.

L.M. Silva, D.S. Menezes andL.E. Almeidaa, The role of the counter-ions present in syntheses on the thermal stabilization of strontium and/or calcium apatites,Mater. Sci. Eng. B 199 (2015) 77-86.

N. Iqbal, M.R.A. Kadir, N.A.N.N. Malek, N.H. Mahmood, M.R. Murali andT.K. Zama, Rapid microwave assisted synthesis and characterization of nanosized silver-doped hydroxyapatite with antibacterial properties,Mater. Lett. 89 (2012)118-122.

S. Lakshmanaperumal and C. Mahendran, Structural, dielectric, cytocompatibility, and in vitro bioactivitystudies of yttrium and strontium co-substituted nanohydroxyapatite by sol–gel method, J. Sol-Gel SciTechn,88 (2018) 296-308.

M.I. AhymahJoshy, K. Elayaraja, R.V. Suganthi, Sarath Chandra Veerla and S. NarayanaKalkura, In vitro sustained release of amoxicillin from lanthanum hydroxyapatite nano rods, CurrAppl Phys. 11 (2011) 1100-1106.

O. Kaygili, S.V. Dorozhkin,T. Ates, N.C. Gursoy, S. Keser, F. Yakuphanoglu andA.B. Selçuk, Structural and dielectric properties of Yttrium-substituted Hydroxyapatites, Mat. Sci. Eng. C 47 (2015)333-338.

E.Landi, A. Tampieri, G. Celotti and S. Sprio, Densification behaviour and mechanisms of synthetic hydroxyapatites, J. Eur. Ceram. Soc., 20 (2000) 2377–2387.

D. Fabio Mercado, GiulianaMagnacca, MeryMalandrino, Aldo Rubert, EnzoMontoneri andLuisellaCeli, Paramagnetic Iron-Doped Hydroxyapatite Nanoparticles with Improved Metal Sorption Properties A Bioorganic Substrates-Mediated Synthesis, ACS Appl. Mater. Interfaces 6 (2014) 3937−3946.

V.Stanic, D.Janackovic, S.Dimitrijevic, S.B.Tanaskovic, M. Mitric and M.S.Pavlovic, Synthesis of antimicrobial monophase silver doped hydroxyapatite nanoparticles for bone tissue engineering, Appl. Sci. 257 (2011) 4510-4518.

Faten E. Al-Hazmi, Synthesis and electrical properties of Bi doped hydroxyapatite Ceramics, J. Alloy. Compd.665 (2016) 119-123.

A.K. Jonscher, The universal dielectric response,Nature 267 (1977) 673-679.

O. Kaygili, T. Ates, S. Keser, A.A. Al-Ghamdiand F. Yakuphanoglu, Controlling of dielectrical properties of hydroxyapatite by ethylenediaminetetraacetic acid (EDTA) for bone healing applications,Spectrochim. Acta A, 129 (2014) 268-273.

O. Kaygili, S.V. Dorozhkin, T. Ates, A.A. Al-Ghamdi and F. Yakuphanoglu, Dielectric properties of Fe doped hydroxyapatite prepared by sol-gel method,Ceram Int. 40 (2014) 9395-9402.

S. Wang, X. Wang, H. Xu, H. Abe, Z.Tan, Y. Zhao, J. Guo, M.Naito, H. Ichikawa and Y. Fukumori, Towards sustained delivery of small molecular drugs using hydroxyapatite micro spheres as the vehicle, Adv Powder Technol.21(2010) 268–272.

P. Yang, Z. Quan, C. Li, X. Kang, H. Lian and J. Lin, Bioactive, luminescent and mesoporous Europium -doped hydroxyapatite as a drug carrier, Biomaterials. 29 (2008) 434-437.

How to Cite
Sundarabharathi, L., Chinnaswamy, M., Parangusan, H., Ponnamma, D., & Ali Al-Maadeed, M. A. (2019). Cytocompatibility and Dielectric Properties of Sr2+ Substituted Nano-Hydroxyapatite for Triggered Drug Release. Frontiers in Advanced Materials Research, 1(1), 18-24.

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