Cytocompatibility and Dielectric Properties of Sr2+ Substituted Nano-Hydroxyapatite for Triggered Drug Release

  • Lakshmanaperumal Sundarabharathi Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India
  • Mahendran Chinnaswamy Department of Physics, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamilnadu, India.
  • Hemalatha Parangusan Center for Advanced Materials, Qatar University, P. O. Box 2713, Doha, Qatar
  • Deepalekshmi Ponnamma Center for Advanced Materials, Qatar University, P. O. Box 2713, Doha, Qatar
  • Mariam Al Ali Al-Maadeed Materials Science and Technology Program, Qatar University, P. O. Box 2713, Doha, Qatar
Keywords: Hydroxyapatite, Sol-gel, doxycycline, Biocompatibility, Bone Implant

Abstract

Hydroxyapatite (Ca5(PO4)3OH) is a well-known bioceramics material used in medical applications because of its ability to form direct chemical bonds with living tissues. In this context, we investigate the biocompatibility and dielectric properties of Sr2+-substituted hydroxyapatite nanoparticles were synthesized by sol-gel method. The influence of strontium on the crystal structure, functional group, morphological, electrical properties, and biocompatibility of as-synthesized nano-hydroxyapatite samples was analyzed using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FE-SEM). Dielectrical properties of the bioactive Sr-HA sample were investigated by a dielectric impedance spectroscopy method. The observed results illustrate the incorporation of Sr2+ ions in the apatite lattice could influence the pure HA properties, by reducing the crystallite size and crystallinity quite consistent with the morphology variation. The ac conductivity (σac) increased with an increasing applied frequency confirmed that prepared HA sample exhibited the universal power law nature. Further, the in vitro drug loading and release studies using doxycycline as a model drug demonstrate that the Sr2+ -HA nanoparticles show high drug adsorption capacity and sustained drug release. Thus, the improved bioceramics system could be a promising candidate for future biomedical applications.

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Published
2019-05-30