Process Analysis and Selection for The Production of P-Cumidine

Abstract

P-cumidine is very important intermediate for many chemical and agrochemical industries. The product, Para cumidine is versatile chemical intermediate that has applications in dyes, pharmaceuticals, and herbicides. The major use of para cumidine as an intermediate in the manufacturing of isoproterenol which is a selective herbicide belonging to the family of substituted ureas and acts principally after root absorption, either pre-emergence or post-emergence. There are many different processes from which p-cumidine can be manufactured. But industrially used process is nitration of cumene followed by hydrogenation. The processes for manufacturing of p-cumidine are alkylation of aniline, nitration of cumene followed by hydrogenation, nitration of cumene followed by reduction using caustic lye and Sulphur. But industrially used process is nitration of cumene followed by hydrogenation.